Bulmer JN

Kurlak LO

Mistry HD

Pipkin FB

Williams PJ

Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) promote angiogenesis and vascularisation. We investigated the temporal expression placental adenosine A(2A)R receptor and HIF-1 alpha in early pregnancy and at delivery in normotensive (NT) and pre-eclamptic (PE) women. Results were compared to our previously reported angiotensin receptor data.Expression of A(2A)R and HIF-1 alpha was highest at &lt;= 10 weeks, positively correlated through pregnancy and was higher in PE than NT at delivery. The A(2A)R associated with the AT4R only in early pregnancy. We suggest adenosine and RAS may interact to promote placentation with a potential adaptation to poor placental perfusion in PE. (C) 2015 Elsevier Ltd. All rights reserved

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Placental expression of adenosine A<sub>2A</sub> receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: Interactions with placental renin-angiotensin system

Placental expression of adenosine A<sub>2A</sub> receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: Interactions with placental renin-angiotensin system

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