Bruntner C

Bull AT

Fiedler HP

Goodfellow M

Imhoff JF

Irran E

Nachtigall J

Nicholson G

Schneider K

Sussmuth RD

Zinecker H

Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3 beta and a weak antiproliferative activity against mouse fibroblast cells. The Journal of Antibiotics (2011) 64, 453-457; doi:10.1038/ja.2011.26; published online 20 April 201

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Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp NTK 935

Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp NTK 935

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