Clegg W

Gimenez-Saiz C

Leigh DA

Murphy A

Slawin AMZ

Teat SJ

The structures of the first tertiary amide peptide rotaxanes are established in solution by 1H NMR spectroscopy and in the solid state by X- ray crystallography. The hydrogen bonding networks which template the rotaxane formation \u27live on\u27 in nonpolar solvents and strongly influence either the tertiary amide rotamer distribution or the rate of interconversion between the rotamers depending upon the peptide sequence. The intercomponent interactions - and their influences - can in appropriate cases be \u27switched off\u27 by polar solvents leading to \u27smart\u27 molecular systems which are flexible or adopt several shapes in one environment but transformed to rigid or single-shaped species in another

\u27Smart\u27 rotaxanes: Shape memory and control in tertiary amide peptido[2]rotaxanes

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