Boam DS

Boot-Handford RP

Chambers D

Grant ME

Howard C

Thomas JT

Wallis GA

Young DA

Type X collagen expression is restricted to hypertrophic chondrocytes in the endochondral growth plate. Transient transfection of reporter constructs containing the human collagen X promoter into primary growth plate chondrocytes identified a cis-acting positive regulatory DNA element(s) that has cell-specific enhancer properties and binds a nuclear protein expressed specifically in growth plate chondrocytes. Functional disruption of this region results in a significant reduction in the activation of reporter gene transcription. The identified enhancer is a major element controlling both high-level and cell-specific expression of type X collagen gene

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An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene

An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene

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