Anaerobic glycolysis in yeast perturbed by the reduction of xenobiotic
ketones is studied numerically in two models which possess the same topology
but different levels of complexity. By comparing both models' predictions for
concentrations and fluxes as well as steady or oscillatory temporal behavior we
answer the question what phenomena require what kind of minimum model
abstraction. While mean concentrations and fluxes are predicted in agreement by
both models we observe different domains of oscillatory behavior in parameter
space. Generic properties of the glycolytic response to ketones are discussed