Sun, Xiaoqing

English

Pulmonary hypertension (PH) is a disease characterized by an increased blood pressure in the pulmonary vascular system, ultimately leading to right ventricular failure (RVF) and premature death. Pulmonary arterial hypertension (PAH), PH group, is defined by an increase in mean pulmonary artery pressure (mPAP) ≥ 20 mmHg, pulmonary wedge pressure ≤ 15 mmHg, and pulmonary vascular resistance > 3 wood units measured by right heart catheterization. This thesis aimed to investigate novel promising treatment strategies for PAH and PAH induced RVF, based on multiple pathological mechanisms underlying the disease. I investigated drugs impacting on the bone morphogenetic protein type 2 receptor (BMPR2) signaling pathway (Chapter 2-4), on growth factor signaling (Chapter 5), on histone acetylation (Chapter 6), as well as several therapeutic strategies specifically targeting the RV (Chapter 7-9)

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VU Research PortalNovel treatment targets for pulmonary arterial hypertension and right ventricularfailureSun, Xiaoqing2021document versionPublisher's PDF, also known as Version of recordLink to publication in VU Research Portalcitation for published version (APA)Sun, X. (2021). Novel treatment targets for pulmonary arterial hypertension and right ventricular failure.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.E-mail address:vuresearchportal.ub@vu.nlDownload date: 23. May. 2021      VRIJE UNIVERSITEIT     NOVEL TREATMENT TARGETS FOR PULMONARY ARTERIAL HYPERTENSION AND RIGHT VENTRICULAR FAILURE        ACADEMISCH PROEFSCHRIFT  ter verkrijging van de graad Doctor of Philosophy aan de Vrije Universiteit Amsterdam, op gezag van de rector magnificus prof.dr. V. Subramaniam, in het openbaar te verdedigen ten overstaan van de promotiecommissie van de Faculteit der Geneeskunde op woensdag 2 juni 2021 om 11.45 uur in de aula van de universiteit, De Boelelaan 1105           door  Xiaoqing Sun  geboren te Shandong, China              promotoren: prof.dr. H.J. Bogaard  prof.dr. M.J.T.H. Goumans     copromotor: dr. F.S. Handoko-de Man    

Novel treatment targets for pulmonary arterial hypertension and right ventricular failure

https://research.vu.nl/files/128824224/X  Sun - title_page.pdf

Novel treatment targets for pulmonary arterial hypertension and right ventricular failure

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