This study develops and evaluates the CAI power point presentation in Genetics (GENCAI). Likewise, it tests the effectiveness of the said material as a teaching tool based on the achievement scores of the Biology students.The research sample was composed of two intact classes of 45 students. They were taken from the second year, high school level of Siena College, Taytay, Rizal (SCT).GENCAI was developed and then assessed by the computer and biology experts from ABS-CBN and DLSU, respectively, three biology teachers and junior high school students of SCT, the feedback of whom were considered in revising the material before it was presented to the experimental group. Results of the achievement exam were statistically analyzed using one way ANCOVA.Accumulated data have shown the following results: 1) the developed GENCAI was judged as a good teaching tool based on the rating given by the evaluators 2) the technical aspect, however, particularly the graphics used in the developed GENCAI, was only given a fair rating and therefore it can be further improved 3) there is a significant correlation between the achievement scores of the experimental group and their exposure to the GENCAI. The experimental group obtained a relatively higher score than those of the control group
