ASO Hisashi

FURUKAWA Mutsumi

NIIMI Kanae

NOCHI Tomonori

UCHINO Saeka

USAMI Katsuki

WATANABE Kouichi

紀要類（bulletin）Session for Studentsdepartmental bulletin pape

USAMI, Katsuki

NIIMI, Kanae

FURUKAWA, Mutsumi

UCHINO, Saeka

WATANABE, Kouichi

ASO, Hisashi

NOCHI, Tomonori

Tohoku University Repository (TOUR) / 東北大学機関リポジトリ

Identification of the Mechanism Responsiblefor Maternal IgA Secretion That Depends on theGut Microbial Stimulation in Peyer's Patches著者 USAMI Katsuki, NIIMI Kanae, FURUKAWA Mutsumi,UCHINO Saeka, WATANABE Kouichi, ASO Hisashi,NOCHI Tomonorijournal orpublication titleJournal of Integrated Field Sciencevolume 18page range 41-41year 2021-03URL http://hdl.handle.net/10097/00131394 41Session for StudentsIdentification of the Mechanism Responsible for Maternal IgA Secretion That Depends on the Gut Microbial Stimulation in Peyer’s PatchesKatsuki USAMI1,2, Kanae NIIMI1,2, Mutsumi FURUKAWA1,2, Saeka UCHINO1,2, Kouichi WATANABE1,2,  Hisashi ASO1,2 and Tomonori NOCHI1,21International Education and Research Center for Food and Agricultural Immunology 2Graduate School of Agriculture Science, Tohoku UniversityImproving breastfeeding quality increases mammalian health across generations. Although the interorgan network among distinct tissues has been implicated in maintaining essential behaviors, including breastfeeding, most details remain unknown. We discuss the essential role of Peyer’s patches (PPs), a secondary lymphoid tissue in the small intestine, in breastfeeding. Specifically, PPs constitute an important source of plasma cells, recruited from the mammary glands, to produce maternal IgA, which is transferred from the mother to the offspring through breastfeeding. A more significant advance in this study was that limited intestinal microorganisms belonging to Bacteroidales were identified as essential bacteria in the gastrointestinal tract for stimulating the immune functions in PPs to produce maternal IgA in milk. Our results provide significant insights into the development of novel strategies for transferring sufficient amounts of maternal IgA to the next generation via breastfeeding.

Identification of the Mechanism Responsible for Maternal IgA Secretion That Depends on the Gut Microbial Stimulation in Peyer's Patches

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Identification of the Mechanism Responsible for Maternal IgA Secretion That Depends on the Gut Microbial Stimulation in Peyer\u27s Patches

Identification of the Mechanism Responsible for Maternal IgA Secretion That Depends on the Gut Microbial Stimulation in Peyer\u27s Patches

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Tohoku University Repository (TOUR) / 東北大学機関リポジトリ