Repetitive behaviors are associated with a variety of disorders in humans and are diagnostic for autism spectrum disorders. Repetitive behaviors can be modeled in rodents. In our previous experiments, we have been able to reduce repetitive circling behaviors in mice using a ketogenic diet. The mechanisms behind the ketogenic diet are still under investigation. Previous investigations have indicated that the ketogenic diet plays a role in neurotransmitter functioning. This study sought to investigate the potential role of neurotransmitters in repetitive behaviors by investigating how three drugs (L-741,626, a dopamine receptor antagonist; CGS21680, an adenosine agonist; & CDPPB, a glutamate positive allosteric modulator) affected circling behavior. Circling behavior was measured using photobeam activated locomotor chambers. Individual doses of each drug as well as a “triple cocktail” consisting of all three drugs were utilized during the experiments. Results indicate that systemic injection of the single drug and triple drug cocktail were not able to reduce circling behavior
