How to optimize metabolites concentrations and fluxes in a metabolic pathway? Backgrounds and Basics

Abstract

The modelling of metabolic pathways is developed here for application to sugar metabolism of tomatoes during fruit expansion. In the now classic calculation of network fluxes, we add concentrations. Under assumptions of steady state and of "minimal effort" as proposed in [1], fluxes and concentrations, respecting constraints of experimental measurements and of thermodynamics, are searched. In order to obtain a well-posed problem, a preliminary mathematical study is in progress