Stroke remains the most important medical and social problem due to its high prevalence among all cerebrovascular diseases, as well as a leading position in the structure of overall morbidity and mortality of the population. This article examines new approaches to improving the effectiveness of management of patients in the acute period of CEI based on more accurate diagnosis, prediction of its course and outcomes, and optimization of neuroprotective therapy. In Uzbekistan, the number of patients with brain stroke is quite large-about 40-45 thousand cases of brain stroke are registered annually. Among the known subtypes of ischemic stroke, cardioembolic stroke (CEI) is particularly difficult to diagnose and treat, which is more severe than other subtypes. This article examines new approaches to improving the efficiency of management of patients in the acute period of cardioembolic stroke, based on more accurate diagnosis, prediction of its course and outcomes, and optimization of neuroprotective therapy