Allen DG

Bers DM

Boerth RC

Chapman RA

Gibbs CL

Jennings RB

Lawson JWR

Shen AC

Shigekawa M

Shine KI

Veech RL

Weiss J

Wendt-Gallitelli MF

Williamson JR

There is good evidence that elevated [Ca2+]i, produced by an influx of Ca2+ in exchange for Na+, is the underlying pathology in reperfusion or reoxygenation damage. Further measurements of [Na+]i and [Ca2+]i during ischemia and reperfusion, coupled with information about metabolic levels, are needed to confirm or refute this hypothesis. Contributions to cell damage by other mechanisms, e.g., oxygen free radicals, certainly cannot yet be excluded.</jats:p

D G Allen

C H Orchard

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Circulation Research

Myocardial contractile function during ischemia and hypoxia.

Myocardial contractile function during ischemia and hypoxia.

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