Myanmar Earthquake (M=6.8) occurred on 24 August 2016 at 10:34 UTC. Anomalies are expected on the surface temperature and other atmospheric parameters. The thermodynamic equilibrium of the troposphere is very much connected with these meteorological parameters. The data of ionospheric variability, air temperature and relative humidity are taken from Chauk Historical Weather, Myanmar ground stations and analysed through origin 5.0 software. The variations of these parameters during the pre-and post-periods of this earthquake from 1 August 2016 to 31 August 2016 are studied in this work. A secondary response before 8 to 9 days and a primary response before 3 to 4 days before the occurrence of this earthquake are obtained. The radioactive Isotopes generate the geothermal energy during decay, distributed between the rock and the natural fluid contained in its fracture regions developed due to the plate movement in the Sunda Trench regions. The stored energy is emitted in the form of heat from earth crust through fractured places and results the anomalous surface latent heat increase before a strong earthquake in the preparation zone. The anomalous surface latent heat causes the variations of air temperature, atmospheric pressure, relative humidity, rainfall and wind speed