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Skin Bleaching Among African and Afro-Caribbean Women in New York City: Primary Findings from a P30 Pilot Study
Authors
Andrew Alexis
Chitra Amarasiriwardena
+14 more
Emma K.T. Benn
Christopher A.D. Charles
Richa Deshpande
Ogonnaya Dotson-Newman
Sharon Gordon
Bridget Kaufman
Ikhlas A. Khan
Bian Liu
Nihal Mohamed
Hector Moran
Marian Scott
Yan Hong Wang
Chi Wen
Novie O.M. Younger
Publication date
24 April 2019
Publisher
eGrove
Doi
Cite
Abstract
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Coinciding with the increase in sequenced bacteria, mining of bacterial genomes for biosynthetic gene clusters (BGCs) has become a critical component of natural product discovery. The order Myxococcales, a reputable source of biologically active secondary metabolites, spans three suborders which all include natural product producing representatives. Utilizing the BiG-SCAPE-CORASON platform to generate a sequence similarity network that contains 994 BGCs from 36 sequenced myxobacteria deposited in the antiSMASH database, a total of 843 BGCs with lower than 75% similarity scores to characterized clusters within the MIBiG database are presented. This survey provides the biosynthetic diversity of these BGCs and an assessment of the predicted chemical space yet to be discovered. Considering the mere snapshot of myxobacteria included in this analysis, these untapped BGCs exemplify the potential for natural product discovery from myxobacteria
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eGrove (Univ. of Mississippi)
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oai:egrove.olemiss.edu:pharmac...
Last time updated on 16/04/2021
FigShare
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Last time updated on 30/05/2019