In this study, it was aimed to develop, characterize, and improve the antioxidant activity of gallic acid (GA) byformulating it into microemulsion (ME) and microemulsion gel (MEg). Blank MEs were prepared using differentproportions of oil/water/surfactant, which provide stable and transparent ME production. Their droplet sizes, zeta potentialsand stabilities after holding, centrifugation, and freeze-thawing processes were determined. F2 and F5 coded MEs wereselected among the blank MEs and GA was loaded into these formulations. Besides the characterization studies, pH andviscosity measurement, in vitro release, cytotoxicity test, cell permeation, and antioxidant activity studies were performed.In vitro released amount of GA was enhanced by formulating it into ME and MEg at the end of six hours and it showed ascavenging effect of DPPH● and ABTS●+ radicals. In conclusion, increased efficacy, reduced toxicity, and prolongedantioxidant activity have been achieved with the use of new, non-toxic, and stable ME and MEg loaded with GA and it isthought that these formulations create the potential for topical application.</p
