Atlas-assisted segmentation of cerebral structures of mice

Abstract

International audienceThe segmentation of different cerebral structures of mice is becoming more and more important due to the growing interest in finding small animal models of human diseases. In this work, variational atlases are constructed by manual segmentation of various MRI brain images of reference and trisomy 21 mice. These atlases are then registered to assist the segmentation of fine cerebral structures such as the cerebellum and the hippocampus. A modified Chan-Vese segmentation method is used for the detection of these structures. Global as well as local comparison of the reconstructed surfaces and volumes are hence conducted to better understand the gene involved in the morphological malformations associated to trisomy