This chapter presents a lower limb exoskeleton mechatronic design. The design aims to be used as a walking support device focused on patients who suffer of partial lower body paralysis due to spine injuries or caused by a stroke. First, the mechanical design is presented and the results are validated through dynamical simulations performed in Autodesk Inventor and MATLAB. Second, a communication network design is proposed in order to establish a secure and fast data link between sensors, actuators, and microprocessors. Finally, patient‐exoskeleton system interaction is presented and detailed. Movement generation is performed by means of digital signal processing techniques applied to electromyography (EMG) and electrocardiography (EEG) signals. Such interaction system design is tested and evaluated in MATLAB whose results are presented and explained. A proposal of real‐time supervisory control is also presented as a part of the integration of every component of the exoskeleton
