Efficient transportation is an important factor for regional socio-economic growth. Excitations from wind loads and road motions can influence vehicle-driver behaviour in a way that may impair transportation. This is especially true in open areas such as long-span bridges. This paper investigates the influence of wind loads and floating bridge motions on bus lateral stability for the straight concept solution across Bj\uf8rnafjorden in Norway. For thisinvestigation, an 8-degree-of-freedom model of a two-axle coach is used. The defined driver model is based on the pure pursuit path tracking method. The vehicle deviation from the path is found to increase with increasing bus speed. This deviation is significant after the vehicle enters the bridge (e.g., over 0.5 m for a speed of 90 km/h). At 108 km/h, the windward rear wheel loses contact, indicating the potential risk of vehicle roll-over. The mean androot-mean-square values of the handwheel steering angle increase with increasing speed, which might cause difficulty for the driver to control the vehicle. Simulation results suggest that the bus can suitably enter the bridge at a lower speed (e.g., 72 km/h) with the possibility of increasing the speed (up to 90 km/h) after approximately 2 km of travelled distance