A Systems Approach to Understanding Bone Cell Interactions in Health and Disease

Abstract

Bone is an important organ performing three essential physiological functions: mechanical support, mineral homeostasis (such as calcium and phosphate) and support of haematopoiesis. In fact, bone diseases in the elderly are associated with high morbidity and increased mortality. Osteoporosis and related skeletal complications are amongst the most important diseases impacting both the quality of life of our aging population and contributing costs to our health care system