Angiography (mostly computed tomography, but in some cases, conventional) is still the gold diagnostic standard in the clinical diagnosis of pulmonary embolism (PE). Computer-aided detection (CAD) is software that alerts radiologists the presence of PE during computerized tomography pulmonary angiography (CTPA) examinations. Interpreting CTPA scans with the aid of commercially available CTPA-CAD has improved the detectability of PE patients. This chapter aims to complete the scope of this book by explaining the clinical evidences of PE, the CTPA technology, the role of CTPA-CAD software in improving the diagnostic abilities of CTPA and the role of conventional pulmonary angiography in daily clinical practice. The reader will be introduced to the performance of diagnosing PE with or without the aid of CTPA-CAD algorithms. Differences among CTPA-CAD’s output will be compared and tabled according to “per patient,” “per clot,” “first reader,” and “second reader” basis. This includes, but not limited to, the CTPA-CAD’s sensitivity and specificity in comparison to human observer performance (i.e., radiologist). These topics cover the current status practice at the pulmonary angiography clinic
