New Pyridine Derivatives As Antiurease Inhibitors: Synthesis and Their Evaluation For Antimicrobial Activities

Abstract

WOS: 0004036308000016-Morpholin-4-ylpyridin-3-amine (3) gathered starting from morpholine by two steps was converted into the corresponding arylidenehydrazides through the reaction with several aromatic aldehydes. The treatment of compound 3 with phenylisothiocyanate generated N-(6-morpholin-4-ylpyridin-3-y1)-N-phenylthiourea (6). The synthesis of 1,3-thiazolidine (7) and 1,3-thiazole derivatives was performed from the reaction of 6 with 4-chlorophenacyl bromide and ethyl bromoacetate, respectively. All synthesized compounds were inspected for their antimicrobial and antiurease activites.Giresun University, Scientific Research Project Unit (GUBAPB) [FEN-BAP-A-140316-31]The authors thanks to Giresun University, Scientific Research Project Unit (GUBAPB) for financial support of FEN-BAP-A-140316-31 and Jasemin

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