Given the concern with the practice of healthy sport activities, the aim of this study is to find what levels of eudaimonic psychological well-being (Ryff, 1989a) and general health, related with their perceived autonomy, and their record of sports injuries in 85 football players in Mexico. We used the Escala de Bienestar Psicológico, EBP, Díaz et al., 2006 to measure psychological well-being. Perceived autonomy was assessed by the Escala de Autonomía Percibida en el Deporte (Balaguer, Castillo and Duda, 2008) and general and emotional health by the Spanish version (Sánchez and Dresch, 2008) of the 12-item General Health Questionnaire (GHQ-12, Goldberg and Hillier, 1979). Also, records of injuries were assessed using an ad hoc questionnaire derived from the Global psychological model of sports injuries (Olmedilla and Garcia-Mas, 2009). The results show that players have a bad perception of general and emotional health, but have good levels of psychological well-being in relation to their perceived autonomy. The number of injuries -not their duration- is related to their poor perception of general and emotional health while it is negatively related to the volitional aspect of perceived autonomy. Their injuries are seen to be frequently associated with pre-competitive anxiety and stress