Pathofysiologie, epidemiologie en therapie bij verouderin

Vinkers, D.J.

NARCIS 

Atheroslerosis, cognitive impairment, and depression in old age.

Leiden University Scholary Publications

Atherosclerosis, cognitive impairment, and depression in old ageDavid Vinkers Atherosclerosis, cognitive impairment, and depression in old age Proefschrift er verkrijging van de graad van Doctor aan de Universiteit Leiden,  op gezag van de Rector Magnificus Dr. D.D. Breimer, hoogleraar in de faculteit der W iskunde en  Natuurwetenschappen en die der Geneeskunde,volgens besluit van het College voor Promoties te verdedigen op donderdag 15 september 2005 klokke 16.15 uur doorDavid Johannes Vinkers geboren te Dodewaard in 1975 tPromotiecommissiePromotor:   Prof. dr. R.G.J. Westendorp Copromotores: Dr. J. Gussekloo    Dr. R.C. van der Mast   Referent:   Prof. dr. M.M.B. Breteler, Erasmus Universiteit Rotterdam Overige leden:  Prof. dr. F.G. Zitman    Prof. dr. R.A.C. Roos Atherosclerosis, cognitive impairment, and depression in old age.  Cover: "Regelmatige Vlakverdeling E85" by M.C. Escher, © 2004 The M.C. Escher Company B.V. – Baarn – Holland. Alle rechten voorbehouden. Printing by Optima Grafische Communicatie, Rotterdam Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged. The Netherlands Organisation for Scientific Research (ZonMw), the Internationale Stichting Alzheimer Onderzoek, Alzheimer Nederland and the J.E. Jurriaanse Stichting contributed in the production costs of this thesis.© David Vinkers No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without permission of the author, or, when appropriate, of the publishers of the publication. Alles in allem genommen haben wir hier offenbar einen eigenartigen Krankheitsproze  vor uns.(Alzheimer A, Über eine eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift für Psychiatrie 1907; 64: 146-48.)Manuscripts based on this thesis Chapter 1 Vinkers DJ, Gussekloo J, van der Mast RC, Zitman F, Westendorp RG. Benzodiazepine use and risk of mortality in individuals aged 85 years or older. JAMA 2003; 290: 2942-43. Chapter 2 Vinkers DJ, Gussekloo J, Westendorp RG. Leisure activities and the risk of dementia. N Engl J Med 2003; 349: 1290-92. Chapter 3 Vinkers DJ, Gussekloo J, Stek ML, Westendorp RG, van der Mast RC. The 15-item Geriatric Depression Scale (GDS-15) detects changes in depressive symptoms after a major negative life event. The Leiden 85-plus Study. Int J Geriatr Psychiatry 2004; 19: 80-84.Chapter 4 Stek ML, Vinkers DJ, Gussekloo J, van der Mast RC, Beekman ATF, Westendorp RGJ. The natural history of depression in the oldest old. A population-based prospective study. Br J Psychiatry, in press. Chapter 5 Vinkers DJ, Stek ML, Gussekloo J, van der Mast RC, Westendorp RG. Does depression in old age increase only cardiovascular mortality ? The Leiden 85-plus Study. Int J Geriatr Psychiatry 2004; 19: 852-57. Chapter 6 Stek ML, Vinkers DJ, Gussekloo J, Beekman AT, van der Mast RC, Westendorp RG. Is depression in old age fatal only when people feel lonely ? Am J Psychiatry 2005; 162: 178-80.Chapter 7 Vinkers DJ, Gussekloo J, Stek ML, Westendorp RG, van der Mast RC. Depression and cognitive impairment in old age: what comes first ? The Leiden 85-plus Study. BMJ2004; 329: 881.Chapter 8 Vinkers DJ, Stek ML, van der Mast RC, de Craen AJM, Le Cessie S, Jolles J, Westendorp RGJ, Gussekloo J. Generalized atherosclerosis, cognitive function, and depressive symptoms in old age. Neurology 2005; 65: 107-12.Chapter 9 Vinkers DJ, van der Mast RC, Stek ML, Westendorp RGJ, Gussekloo J.  Disentangling the relation between atherosclerosis, cognitive impairment and late-onset depression.ContentsIntroduction           8 Chapter 1  The Cox proportional-hazards model      11Chapter 2  The linear mixed model       15 Chapter 3  The repeated use of the 15-item Geriatric Depression Scale   19 Chapter 4 The natural history of depression in old age     29 Chapter 5 Does depression in old age increase cardiovascular mortality ?  39 Chapter 6 Depression leads to mortality only when feeling lonely   51 Chapter 7  Depression and cognitive impairment in old age: what comes first ? 59 Chapter 8  Atherosclerosis, cognitive impairment, and depression in old age  71 Chapter 9 Disentangling the relation between atherosclerosis, cognitive  85 impairment and depression in old age    Samenvatting           99 Nawoord            105 Curriculum Vitae          107

https://scholarlypublications.universiteitleiden.nl/access/item%3A2958865/download

Atheroslerosis, cognitive impairment, and depression in old age.

Abstract

Similar works

Full text

Available Versions

NARCIS

Leiden University Scholary Publications