'Medical University Prof. Dr. Paraskev Stoyanov - Varna'
Doi
Abstract
During the last few decades the interest in the synthesis and investigation of different coumarin derivatives and analogues has vastly increased mostly due to their multidisciplinary application in organic synthesis, agrochemistry, medicine, laser technologies, and etc. The object of our investigations is concerned on the chemical behaviors of these compounds because they are good acceptors in reactions with nucleophillic reagents, they can be used as dienophiles in Diels-Alder reaction, 1,3-bipolar cycloaddition reactions etc. The combination of coumarin structure and phosphono moiety assumes a biological activity, which can be a result of each of both units as well as a blend of both. It is clear that coumarins can be used as ligands in complexes with variety metal ions. Another aspect about coumarins which is of great interest for us is the possible photochemical properties of these compounds.Here we report reactions of cycloaddition and new rearrangement reaction resulting in potential biologically active derivatives
