Ivanova, E.

Marinov, G.

Tabakov, T.

English

Varna Medical University Press: Journals

SOME A G E P E C U L I A R I T I E S OF T H E W A L L S T R U C T U R E OF ILIAC A R T E R I E S G. Marinov, T. Tabakov, E . Ivanova The age peculiarities of the wall structure of iliac arteries reveal certain interest because of the bibliographic data about prenatal constructive disor-ders (Marinov, Tabakov — 1980) combined with changed metabolism of cal-cium (Meyer— 1968) and lipides (Sinzinger et a l . — 1975). This metabolism plays an important role for the development of atherosclerotic processes located in the cited zone; therefore, the object of the present study was to study the constructive peculiarities during pre- and post-natal ontogenesis. The investigation of these vessels is actual also due to the fact that the three iliac arteries: common, internal and external are located next to each other, in similar conditions. But because of their different calibre and deviation-angle they possess various functional duties. Al l that allows the thorough analysis of the influence of the aforementioned factors upon the structure of the arterial wal l . Materials and methods " The study covers three age-groups (corpses from the Department of Ana-tomy, Higher Institute of Medicine): I — 10 foetuses with length of 13—39,5 cm (serial histological cuts with thickness 6 micromicrons, interval 60—180 micro-microns, were prepared); I I — 6 children between 3 and 4V 2 years; I I I — 6 people died at the age of 9, 13, 18, 39, 55 and 88 years. 75 preparations from magistral zones of the three vessels (far from the places of the branches) were studied (the preparations are from both I I and I I I group). Staining with hema-toxylin-eosin, with orcoin and after the method of Van Gieson was applied. Results and discussion The preparations from the foetuses of I group show thin intima of the stu-died arteries; it has only one layer endothelium and well developed homoge-neous elastic inner membrane. Their media is also thin with several rows of circular-orientated smooth-muscle cells. The longer the foetuses are the thicker the wall of their iliac arteries is. There is a certain variety of the structure of these zones which can be divided into 3 main types: I — local projections of intima with small sizes as a result of developing thin subendothelial layer and double inner elastic membrane (either by splititing of the membrane into two ideally equal lists or by forming of elastic lamellas inside or outside of the inner elastic membrane). These formations are identical to those reported by Vankov, Nikolov, Chaldukov (1974) for the intima development in post-natal organogenesis, but in our cases we establish them prenatally. I I — in-tima projections with bigger sizes located only in the intima with massive Some age peculiarities of the wall structure of iliac. 125 subendothelial layer and proliferation of smooth-muscle cells orientated longi-tudinally or transversally. In these zones the inner elastic membrane forms 2 lists — subendothelial and subintimal with a destroyed integrity (some-times). I l l — bundles of longitudinally orientated muscles in the media with deeply changed elastic skeleton. This leads to splitting of media particles and F i g . 1 a, b formation of massive intimal projections. Similar data, but concerning other arteries, reports Robertson (1960). Later we established them in the femoral artery (Marinov — 1977; Marinov, Tabakov — 1980) and in the present s t u d y -in the common and internal iliac arteries during prenatal development. The sizes and thickness of intimal projections from I I type are quite considerable; therefore we presume it wil l be suitable if we define them dntimal thickenings» (fig. 1 - a, b). The serial study of histological cuts and graphical reconstruction of the length of iliac arteries of foetuses ( I group) allows the location of the describ-ed intimal thickenings from proximally to distally: 1) Bifurcation of the ab-dominal aorta — proximal zone of the common iliac artery. 2) Bifurcation of the common iliac artery — extent of the internal iliac artery. 3) Zone of little branches of the external iliac artery proximally of the inguinal plica. From the cited 3 locations the first 2 are more constant and with considerably bigger sizes. 126 G. Marinov, Т. Tabakov, Е. Ivanova Children aged 3—4 years show thinnest wall of their external iliac artery compared to the other two iliac arteries. Its intima is thin and equally deve­loped along the whole vessel's lumen. I t is formed by 1 or 2 elastic membra­nes.— subendothelially or subintimally. Between both membranes is located ajthin connective-tissue layer with single muscle fibres longitudinally orientated. Fig . 2 The media of the external iliac artery in this age is built only by circular mus­cles with equal thickness of the lumen. The wall of the common and specially internal iliac arteries is irregularly thick and with various structure of the lu­men. There are thicker and thinner regions (fig. 2) which is due to intimal projections of I I and I I I type, i . e. those ones which involve only intima or intima and media together (fig. 3 — a, b). Projections from I I type are capable of involving up to l / a of the vessel's lumen whereas those from I I I type -Щ of it. The thickness is contradictory — I I I type shows thicker wall than : I I one/Projections from I I and I I I type are quite oftener in internal iliac artery than in external artery and in common one (in this age no projections are estab­lished in external artery). The different structures of the three iliac arteries can be explained with the various angle of deviation; the common and internal iliac arteries have considerably sharp angle thus providing definite conditions of increased coeffi­cient of local resistance and greater wall burdening. Similar data about coro­nary arteries report Velican and Velican (1978). Besides, the functional burden of the common and internal arteries in embryonal period is bigger due to the activity of the umbillical artery (Meyer— 1968). With age the thickness of intima and media increases several times. The thicker wall corresponds with its more complex qualitative integrity. Intinrai 127 projections from I I and I I I type are registered in the external iliac artery uni-laterally in a 39-year old individual. In the later age — 55 and 88, these pro-jections are more expressed and numerous. In comparison with that these pro-jections and the thickness of intima in the common and internal iliac arteries for the same age-group are quite considerable and more developed. F i g . 3 a, b A l l our data together with the possible influence of some other factors (genetical, immunological, etc.) show that the haemodynamic conditions have an important significance for the construction of the arterial wal l . 128 G. Marinov, Т. Tabakov, Е. Ivanova R E F E R E N C E S 1. Б а н к о в , В . , С. Н и к о л о в , Г. Ч а л д ъ к о в . V I юб. науч. с е е , ВМИ, Варна, 1974, Сборн. докл. , 73—76. — 2. М а р и н о в, Г. Биол. пробл., МА, София, 5, 1977, 49—57. — 3. М а р и н о в. Г., Т. Т а б а к о в . Мед. биол. пробл., МА, 8, 1980, под печат. — 4. M e y e r , W. W. Beitr. Path. Anat., 138, 1968, 149—162. — 5. R o b e r t s o n , J . H . J. Clin. Path., 13, 1960, 133—139. — 6. R o b e r t s o n , J . H . Arch. Dis. Childr., 35, 1960, 588—590. — 7. R o b e r t s o n , J . H . J. Clin. Path., 13, 1960, 199—204. — 8. S i n z i n g е r, H . е t a 1. Path. Microbiol., 43, 1975, 129—133. — 9. V е 1 i с a n, D . , C. V e l i c a n . Acta anat., 100, 1978, 258—267. НЕКОТОРЫЕ ВОЗРАСТНЫЕ[ ОСОБЕННОСТИ СТРУКТУРЫ СТЕНКИ ПОДВЗДОШНЫХ АРТЕРИЙ Г. Маринов, Т. Табаков, Е. Иванова Р Е З Ю М Е Изучены возрастные особенности структуры стенок подвздошных артерий — общей наружной и внутренней. Исследовались три возрастные группы: человеческие плоды» дети с трех до четырех с половиной лет и в возрасте от 9 до 88 лет. Установлены три т и п , утолщения интимы: небольшие очаги утолщения интимы, более значительные утолщениа интимы, которые не затрагивают средней оболочки (медии) и утолщения интимы, которыя образуются за счет пролиферации продольной мускулатуры в средней оболочке с проистее кающим из этого преустройством конструкци стенки. Прослеживаются развитие и эво— .люция этих изменений в возрастном аспекте. 

SOME AGE PECULIARITIES OF THE WALL STRUCTURE OF ILIAC ARTERIES

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SOME AGE PECULIARITIES OF THE WALL STRUCTURE OF ILIAC ARTERIES

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