Georgieva, M.

Georgieva, Zh.

Mileva, V.

English

Varna Medical University Press: Journals

Scripta Scientifica Medica, vol.28, Suppl.1,pp.225-226 Copyright © Medical University, Varna, 1991 INFORMATION VALUE OF PARAMETERS FOR HEART RHYTHM ANALYSIS UNDER CONDITIONS OF ANEMIC HY-POXIA V. Mileva, M. Georgieva, Zh. Georgieva* Department of Physiology, Department of Propedeutics of Internal Diseases, Varna Functional state of cardio-vascular system (CVS) presents an universal indicator of adaptation-adjustment reactions of the organ-ism under conditions of health, disease and of transition between them. Both operative and strategic CVS management is realized by the vegetative and central nervous system and the system of hypo-physis-adrenal glands forming an united neurohormonal complex. Dysbalance in this complex plays an essential role in the pathogen-esis of various diseases affecting directly or indirectly CVS. Dyna-mics of heart rhythm (HR) is a specific reaction of CVS changes, as mean HR frequency reflects the final result from numerous influen-ces on CVS and organisms as a whole. In HR structure and parame-ters originating from it a latent information is coded dealing with dynamic interaction between single management levels and the state and degree of tension in regulatory mechanisms. Analysis of HR par-ameters enables the evaluation of the state of vegetative balance in the organism and of homeo- and heterostasis balance, i.e. of the adaptation of the organism under physiological and pathological changes related to its inner medium or to influences by external fac-tors. A total of 72 females with average age of 32,5 years with chronic posthemorrhagic iron-deficient anemia (IDA) and mean duration of disease of 3,8 ± 2,1 years are studied. IDA is considered a model of anemic hypoxia. Patients are divided into 3 groups: 1 s t - with IDA of light degree (Hb - 97,49 ± 1,37 g/l and serum iron - 9,57 ± 1,83 ixmol/l); 2 n d - with IDA of intermediate severe degree (Hb - 86,37 ± 1,05 g/l and serum iron - 7,74 ± 2,33 pjnol/l), and 3 r d - with IDA of severe degree (Hb - 67,27 ± 1,32 g/l and serum iron - 5,01 ± 1,42 ixmol/l). HR parameters are followed-up at rest and after physical loading (a working test consisting of 20 squattings per 40 sec). HR analysis is ensured by appropriate hard and soft-ware. Indexes in the three directions are estimated. Our results indicate: 1. Changes of parameters in the three directions at rest and after physical load-ing (table 1). 2. Dependence between the degree of anemia and grad-226 uality at the levels of regulation and interaction with other regulatory links. 3. An increasing of the process of "centralization" in HR man­agement in the course of advancing anemia and involvement in an management activity of higherly positioned central-cerebral struc­tures. 4. A state of asthenization of regulatory mechanisms in cases with severe IDA after physical loading (changes of Mo, AMo and d R-R). Table 1 1 9Г. , ШЛ£л III 9Г» 1 _ 2 _ 1 2 1 2 X 885,4 706,3** 821.6 758,3* 621,0 х* 722,3** _SD 71,2 85,9* __6JL3 170,2** 42,5** 98,3** Яр 882,1 712,1** 838,7* 822,2 631,7** 772,3** AM0 9,45 11.12* 9,48 4,69* 20,04 х* 7,93** AR-R 545,9 610,0 х 410,0 х 455,0 X X 320,0** 513,9** П 9,80 18,66** 14,20* 4,84** 49,60** 10,23** •Wl 2,15 2,82 2,93 1,86* 4,95** 2,58* "В* 297,27 7 8 , 8 1 x x 416,75 x x 18 ,34 x x 2385,7** 68,47* x H * 7.fi? Jg-I?**1* 16.15*",_33tSSFH 74..781х 10,45** P t 16,76 27,80** 30 ,40 x x 30,40 23,02 х 31,25 х РЬр 25,57 21,64* 25,10 17,67 х 17 ,50 х х 22,12 P t 38,07 27,42** 27,77* 29,69 35,11* 23,08* « 0,89 1,85** 1,05 1,73* 1,15 2,39** ASiibcI o,65 1,80** 1,21* 1,72 1,31* 1,46 M 0,69 0,80 _ Q z 6 3 _ 0,63 0,49* 1,00* 1 - at rest * p < 0,05 2 - after physical loading ** p < 0,01 We conclude that: 1. Changes of HR parameters and their analysis enable an non­invasive invesigation and evaluation of the state of regulatory system in the organism and of the "price" paid for adaptation towards unfa­vourable conditions. 2. Comparative analysis of HR parameters in­forms about the vegetative security of the organism under conditions of anemic hypoxia. 3. Centralization of processes and disconcord-ance in some of them in severe IDA allows the determination of new therapeutic approaches. 

INFORMATION VALUE OF PARAMETERS FOR HEART RHYTHM ANALYSIS UNDER CONDITIONS OF ANEMIC HYPOXIA

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INFORMATION VALUE OF PARAMETERS FOR HEART RHYTHM ANALYSIS UNDER CONDITIONS OF ANEMIC HYPOXIA

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