Biological, physical and clinical aspects of cancer treatment with ionising radiatio

Abrahamse-Testroote, M.C.J.

Alemayehu, W.G.

Doorduijn, J.K.

Geisler, C.H.

Itala-Remes, M.

Kimby, E.

Kozak, T.

Oers, M.H.J. van

Polliack, A.

Tjonnfjord, G.E.

van't Veer, M.B.

Vojdeman, F.J.

Walewski, J.

Wittebol, S.

Wu, K.L.

In the HOVON68 CLL trial, patients 65 to 75 years of age had no survival benefit from the addition of low-dose alemtuzumab to fludarabine and cyclophosphamide (FC) in contrast to younger patients. The reasons are explored in this 5-year trial update using both survival analysis and competing risk analysis on non-CLL-related mortality. Elderly FCA patients died more frequently from causes not related to CLL, and more often related to comorbidity (mostly cardiovascular) than to infection. In a Cox multivariate analysis, del(17p), performance status >0, and comorbidity were associated with a higher non-CLL-related mortality in the elderly independent of the treatment modality. Thus, while the 'fit' elderly with no comorbidity or performance status of 0 might potentially benefit from chemo-immunotherapy with FC, caution is warranted, when considering alemtuzumab treatment in elderly patients with cardiovascular comorbidit

Vojdeman, Fie Juhl

van't Veer, Mars B.

Tjønnfjord, Geir E.

Itälä-Remes, Maija

Kimby, Eva

Polliack, Aaron

Wu, Ka L.

Doorduijn, Jeanette K.

Alemayehu, Wendimagegn G.

Wittebol, Shulamiet

Kozak, Tomas

Walewski, Jan

Abrahamse-Testroote, Martine C. J.

van Oers, Marinus H. J.

Geisler, Christian Hartmann

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