Berliner D.L.

British Standard Institute (BSI).

Chapuis J.F.

Comparative

Guess W.L.

Lucarz-Bietry A.

Thomas S.

Tulle

Objective: We compared the effects on cultured human fibroblasts of a new non-adhesive wound dressing, Urgotul, with five other wound dressings. Urgotul is a hydrocolloid dressing; the comparator dressings included impregnated gauze and modern wound dressings. Method: Cultures in monolayer were used to study the morphology and growth of fibroblasts. The Bell model of cultured dermis equivalents was used to investigate myofibroblast differentiation. These cultures were labelled a-SM actin and F-actin. Results: Two of the tested dressings induced cytotoxic effects. They were found to inhibit cell growth (greater than 60%) and to disturb cell shape and cytoskeletal differentiation. Urgotul and the remaining three dressings showed no effect on proliferation. However, some of them modified fibroblast morphology and affected F-actin distribution. Conclusion: Depending on their nature and components, wound dressings may respect or affect fibroblast behaviour in vitro (proliferation, morphology and a-SM actin and F-actin distribution). The significance of these in vitro observed findings require further investigations. Declaration of interest: This study was supported by Urgo Laboratories. </jats:sec

C. Viennet

J. Bride

A.C. Gabiot

P. Humbert

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Journal of Wound Care

Comparison of different wound dressings on cultured human fibroblasts and collagen lattices

Comparison of different wound dressings on cultured human fibroblasts and collagen lattices

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