Leids Universitair Medisch CentrumKlinische evaluatie en behandeling van reumatische ziekte

Tchetverikov, I.

Leiden University Scholary Publications

Matrix Metalloproteases Involvement in Rheumatoid Arthritis Ilja Tchetverikov    © 2004, I. Tchetverikov, Leiden, The Netherlands All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior written permission from the author.  Matrix Metalloproteases Involvement in Rheumatoid Arthritis Proefschriftter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr. D. D. Breimer, hoogleraar in de faculteit der W iskunde en Natuurwetenschappen en die der Geneeskunde, volgens besluit van het College voor Promoties te verdedigen op donderdag 17 februari 2005 te klokke 14.15 uur doorIlja Tchetverikov geboren te Leningrad (Sovjet Unie) in 1971    PROMOTIECOMMISSIE Promotores:  Prof. dr. F.C. Breedveld    Prof. dr. T.W.J. Huizinga Copromotor:  Dr. R. Hanemaaijer Referent:  Prof. dr. M. H. van Rijswijk Overige leden:  Prof. dr. M. R. Daha    Dr. J. de Groot Mw. dr. G. Kloppenburg Financial support by Abbot B.V., Aventis B.V., the Dr. Ir. Van de Laar Stichting, the Dutch Arthritis Association, Pfizer B.V. and TNO Pharma for the publication of this thesis is gratefully acknowledged. ISBN 90-9019077-5 “ , ,- ,- ..”(Pardon me for not believing it, - said Woland, - that is not possible.Manuscripts do not burn.) M.A. Bulgakov, The Master and Margarita    ContentsChapter 1 General introduction        9 Chapter 2 Active MMPs captured by alpha2Macroglobulin as a marker of  29 disease activity in rheumatoid arthritis Clinical and Experimental Rheumatology, 2003;21(6):711-8.Chapter 3 MMP activity measurements using low molecular weight  45 fluorogenic substratesSubmitted.Chapter 4 MMP profile in paired serum and synovial fluid samples of 57 rheumatoid arthritis patients  Annals of Rheumatic Diseases, 2004;63(7):881-3.Chapter 5 Matrix Metalloproteinases-3, -8, -9 as markers of disease activity 67 and joint damage progression in early rheumatoid arthritis Annals of Rheumatic Diseases, 2003;62(11):1094-9.Chapter 6 MMP protein and activity levels in synovial fluid of joint injury, 83 arthritis and osteoarthritis patients Annals of Rheumatic Diseases, in press.Chapter 7 Effects of treatment with leflunomide or methotrexate on  97 2Macroglobulin/MMP complexes in serum of rheumatoid  arthritis patients  Submitted.Chapter 8 Summary and general discussion     107 Appendix Nederlandse samenvatting      119 List of abbreviations       127 List of publications       129 Acknowledgments       131 Curriculum Vitae       133    

Matrix metalloproteinases involvement in rheumatoid arthritis

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Matrix metalloproteinases involvement in rheumatoid arthritis

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