Role of cardiac biomarkers in cognitive impairment and functional decline

Abstract

This thesis aimed to investigate the link between cardiac biomarkers, cognitive impairment and functional decline in older subjects with a focus on non-invasive markers that are routinely available in clinical practice. The findings of this thesis show that markers of subclinical cardiac dysfunction are linked with accelerated cognitive decline and a higher risk of functional decline. In addition, we provide preliminary findings on the potential role of centrally acting natriuretic peptides in relation to cognitive impairment. Collectively, these findings highlight a complex pathophysiological heart-brain coupling that might extend beyond vascular and hemodynamic factors. Future studies are needed to investigate whether such link warrants mutual screening of the heart and the brain functions, and whether such practice could improve early diagnosis of dementia. Financial support for printing of this thesis was provided by Leiden University Medical Centre, Alzheimer Nederland and Dutch Heart Foundation.LUMC / Geneeskund