An approved drug is a drug that meets indicators with rational drug use criteria. Identification of DDD values for medical records and prescriptions of outpatients and inpatients using WHO-determined methods. Analysis of rational drug use in a hospital in Bandung using diabetes drugs are Acarbose, Glibenclamide, Glimepirid, Metformin, and Pioglitazon. The use of hypertension drugs are amlodipine, lisinopril, candesartan, bisoprolol, irbesartan, furosemide, hydroclorothiazide, and ramipril. The use of typhoid drugs is chloramphenicol, amoxicillin, cefixime, and levofloxacin. Based on the right criteria the number of rational percentages is 63.43%, the right criteria correspond to the proportion of 95.91%, the right criteria according to the results are 63.43%, and the right criteria based on the results are 46.45%. Keywords: Rational Drug Use, Disease, Bandung City Hospital, DDD Method. DOI: 10.7176/JHMN/86-06 Publication date: February 28th 202