Last several months, the World is witnessing Coronavirus disease 2019 (COVID-19) pandemic caused by the newly identified Coronavirus. Due to the fast and easy disease spread as well as its severity, currently this pandemic is dominating every aspect of the global healthcare systems but also it outstandingly influences every side of our lives including the global economy. Almost all COVID-19 treatment guidelines advocate the rational use of antibiotics, but if we analyse the reports published so far, it is evident that about 70% up to even 100% of patients are treated with antibiotics. This antibiotic misuse highlights the urgent need for launching the Antimicrobial Stewardship Program in order to monitor the appropriate use of antibiotics. In this article, the authors suggest the postulates for implementing the antibiotic stewardship in COVID-19 patients.Posljednjih nekoliko mjeseci svijet je svjedok pandemije COVID-19 izazvane novootkrivenim koronavirusom. Zbog brzog i lakog širenja bolesti, kao i njezine ozbiljnosti, trenutno ova pandemija dominira svim aspektima globalnih zdravstvenih sustava, ali također iznimno utječe na sve aspekte našeg života, uključujući globalno gospodarstvo. Gotovo sve smjernice liječenja COVID-19 zagovaraju racionalnu uporabu antibiotika, ali ako analiziramo do sada objavljena izvješća, očito je da se oko 70% pa čak i do 100% bolesnika liječi antibioticima. Ova zlouporaba antibiotika naglašava hitnu potrebu za pokretanjem programa upravljanja antimikrobnim lijekovima radi praćenja odgovarajuće uporabe antibiotika. U ovom članku autori predlažu postulate za primjenu programa upravljanja antibioticima u bolesnika s COVID-19