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Hyaluronic acid in viscous malignant mesothelioma pleural effusion
Authors
Hui Min Cheah
Jenette Creaney
+3 more
Deirdre Fitzgerald
Y. C.Gary Lee
Amber Louw
Publication date
1 January 2021
Publisher
Edith Cowan University, Research Online, Perth, Western Australia
Abstract
© 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity-dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight
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Last time updated on 03/03/2021