Universidad de Murcia. Departamento de Biología Celular e Histología
Doi
Abstract
Absorbable atelo-collagen type 1 represents a
new approach for guided bone regeneration with several
reported advantages such as: osteoblast attachment,
proliferation, mineralization potential, absorption of
growth factors and inhibition of bacterial pathogen
colonization. The aim of this study was to assess the
clinical, radiological (preoperative width, re-entry width,
gain), Periotest measurements and histologic benefits of
atelo-collagen-derived bovine bone grafts (ImploBone)
in combination with an atelo-collagen type I barrier
membrane (ImploSorb) for guided bone regeneration
(GBR) of atrophic alveolar crest in thirteen patients.
Eleven patients underwent simultaneous GBR with
implant insertion, two had initial GBR procedure
followed by implant placement after 6 months of
healing. Ridge augmentation was performed using an
atelo-collagen membrane (ImploSorb, Bioimplon,
Germany) and a combination of 50% ABBM
(ImploBone, granule size 0.5-1mm, BioImplon
Germany) mixed with 50% autologous bone.
It was found that simultaneous GBR with implant
placement resulted in a 35% gain at bone defect level
(preoperative width 5.03±1.25 mm, re-entry width
6.81±0.98 mm, gain 1.78±1.71 mm). Implant placement
performed in a 2 stage surgery 6 months following GBR
was linked with a 63.9% gain at bone defect level
(preoperative width 3.79±1.10 mm, re-entry width
6.22±1.41 mm, gain 2.43±1.43 mm). The total gain in
both groups was 41.9% utilizing these novel
biomaterials (preoperative width 4.68±1.32 mm, re-entry
width 6.65±1.12 mm, gain 1.96±1.64 mm).
This case series study presents a protocol where
GBR can be performed either simultaneously to implant
placement or delayed with this innovative biomaterial to
favor bone regrowth. Future randomized controlled
clinical trials are needed to further validate the bonepromoting potential of atelo-collagen-based biomaterials
for bone regeneration