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Cortical thickness and anxiety symptoms among cognitively normal elderly persons: The mayo clinic study of aging
Authors
Yonas E. Geda
Clifford R. Jack
+9 more
David S. Knopman
Janina Krell-Roesch
Michelle M. Mielke
Ronald C. Petersen
Anna Pink
Scott A. Przybelski
Rosebud O. Roberts
Kathleen A. Spangehl
Gorazd B. Stokin
Publication date
1 January 2017
Publisher
Barrow - St. Joseph\u27s Scholarly Commons
Abstract
© 2017, American Psychiatric Association. All rights reserved. The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged $70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex. However, after additionally adjusting for comorbid depressive symptoms, only the association between anxiety symptoms and reduced insular thickness remained significant
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Last time updated on 27/02/2021