CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
research
The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma
Authors
A Janssen
AH Marx
+66 more
AJ Lee
AM Dulak
AM Dulak
B Fu
BJ Reid
CA Ong
CD Schweighofer
Christin M. Sciulli
CM Jacobsen
D Choma
D Hanahan
D Hirsch
DJ Nancarrow
DP Cahill
ER Thompson
F Boudreau
G Ng
GA Prasad
George K. Michalopoulos
GJ Kops
H Lango Allen
H Pohl
HJ Stein
J Gu
J Theisen
J. Michael Krill-Burger
James D. Luketich
JC Saldivar
JO Korbel
Jon M. Davison
Katie S. Nason
L Lin
LA Lai
LO Baumbusch
Lori A. Kelly
M Greaves
M Sarbia
M Schweigert
M Tuefferd
Maureen A. Lyons-Weiler
MB Menke-Pluymers
Melissa Yee
N Deng
N McGranahan
NJ Birkbak
NS Chang
O Pech
OM Radu
PJ Stephens
R Beroukhim
R Roylance
S Bayraktar
S Li
SE Araujo
SL Carter
Svetlana Pack
T Nakamura
TM Kim
TW Rice
TW Rice
VI Gaidzik
William A. LaFramboise
WJ Blot
WJ Kent
XY Goh
YJ Bang
Publication date
16 January 2014
Publisher
'Public Library of Science (PLoS)'
Doi
Cite
View
on
PubMed
Abstract
Background: Prognostic biomarkers are needed for superficial gastroesophageal adenocarcinoma (EAC) to predict clinical outcomes and select therapy. Although recurrent mutations have been characterized in EAC, little is known about their clinical and prognostic significance. Aneuploidy is predictive of clinical outcome in many malignancies but has not been evaluated in superficial EAC. Methods: We quantified copy number changes in 41 superficial EAC using Affymetrix SNP 6.0 arrays. We identified recurrent chromosomal gains and losses and calculated the total copy number abnormality (CNA) count for each tumor as a measure of aneuploidy. We correlated CNA count with overall survival and time to first recurrence in univariate and multivariate analyses. Results: Recurrent segmental gains and losses involved multiple genes, including: HER2, EGFR, MET, CDK6, KRAS (recurrent gains); and FHIT, WWOX, CDKN2A/B, SMAD4, RUNX1 (recurrent losses). There was a 40-fold variation in CNA count across all cases. Tumors with the lowest and highest quartile CNA count had significantly better overall survival (p = 0.032) and time to first recurrence (p = 0.010) compared to those with intermediate CNA counts. These associations persisted when controlling for other prognostic variables. Significance: SNP arrays facilitate the assessment of recurrent chromosomal gain and loss and allow high resolution, quantitative assessment of segmental aneuploidy (total CNA count). The non-monotonic association of segmental aneuploidy with survival has been described in other tumors. The degree of aneuploidy is a promising prognostic biomarker in a potentially curable form of EAC. © 2014 Davison et al
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
FigShare
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:figshare.com:article/90249...
Last time updated on 12/02/2018
Crossref
See this paper in CORE
Go to the repository landing page
Download from data provider
info:doi/10.1371%2Fjournal.pon...
Last time updated on 26/02/2019
Name not available
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:d-scholarship.pitt.edu:218...
Last time updated on 23/11/2016
D-Scholarship@Pitt
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:d-scholarship.pitt.edu:218...
Last time updated on 17/07/2014
Public Library of Science (PLOS)
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 05/06/2019
Name not available
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:d-scholarship.pitt.edu:218...
Last time updated on 15/12/2016
Public Library of Science (PLOS)
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 18/09/2018
Directory of Open Access Journals
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:doaj.org/article:c73657a7d...
Last time updated on 13/10/2017