AIM: We want to investigate the protective effects of apelin-13 on
myocardial ischemia reperfusion (I/R) injury.
MATERIAL AND METHODS: 30 Wistar Albino rat were divided into 5 groups
(n:6), namely control group (C), diabetes group (D), diabetes+apelin-13
group (DA), diabetes+I/R group (DIR) and diabetes I/R+apelin-13 group
(DIR-A). Rats were subjected to 30-min ischemia and 90-min reperfusion.
Biochemical and histopathological parameters were measured.
RESULTS: Caspase-3 enzyme activity was significantly higher in the DIR
group than in the C, DA, and DIR-A groups. The intensity of caspase 3
enzyme activity was significantly higher in the I/R group than in all
other groups. Inflammation and vascular dilatation were found
significantly higher in the DIR group than in all other groups.
Congestion was significantly higher in the DIR group than in the C and D
groups. TOS enzyme activity was significantly higher in the DIR group
than in the C, DA and DIR-A groups. TAS enzyme activity was
significantly lower in the DIR group than in the C and DIR-A groups.
CONCLUSION: We believe that the protective effects of apelin-13 in
ischemia-reperfusion injury and its use indications can be demonstrated
in detail as long as the findings we have reached in our study are
supported by other studies (Tab. 2, Fig. 10, Ref. 43)