Eri  Miyamoto-Mikami

Hirofumi  Zempo

Hiroshi  Kumagai

Hisashi  Naito

Kosuke  Hirata

Naokazu  Miyamoto

Naoki  Kikuchi

Nobuhiro  Kamiya

Noriyuki  Fuku

Seigo  Hoshikawa

P(論文)https://www.tsc-05.ac.jp/pdf_library/2020.pdfdepartmental bulletin pape

Kumagai, Hiroshi

21683

Miyamoto-Mikami, Eri

21684

Hirata, Kosuke

21685

Kikuchi, Naoki

21686

Kamiya, Nobuhiro

21687

Hoshikawa, Seigo

21688

Zempo, Hirofumi

21689

9000399500957

Naito, Hisashi

21690

Miyamoto, Naokazu

21691

Fuku, Noriyuki

21692

Tokyo Seiei College Repositories / 東京聖栄大学 リポジトリ

－ 1 － 再録 報文 Med Sci Sports Exerc. 2019;51(1):19-26. ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness.  Hiroshi Kumagai1,2, Eri Miyamoto-Mikami1,3, Kosuke Hirata3, Naoki Kikuchi4,  Nobuhiro Kamiya5, Seigo Hoshikawa1,6, Hirofumi Zempo7, Hisashi Naito1,  Naokazu Miyamoto3, and Noriyuki Fuku1 1Graduate School of Health and Sports Science, Juntendo University. 2Research Fellow of Japanese Society for the  Promotion of Science. 3Department of Sports and Life Science, National Institute of Fitness and Sports in Kanoya.  4Department of Training Science, Nippon Sport Science University. 5Faculty of Budo and Sport Studies, Tenri  University. 6Edogawa University. 7Faculty of Health and Nutrition, Tokyo Seiei College.  Abstract Purpose: Muscle injury is the most common sports injury. Muscle stiffness, a risk factor for muscle injury, is lower in females than in males, implying that sex-related genetic polymorphisms influence muscle injury associated with muscle stiffness. The present study aimed to clarify the associations between two genetic polymorphisms (rs2234693 and rs9340799) in the estrogen receptor 1 gene (ESR1) and muscle injury or muscle stiffness.  Methods: In study 1, a questionnaire was used to assess the muscle injury history of 1311 Japanese top-level athletes. In study 2, stiffness of the hamstring muscles was assessed using ultrasound shear wave elastography in 261 physically active young adults. In both studies, rs2234693 C/T and rs9340799 G/A polymorphisms in the ESR1 were analyzed using the TaqMan SNP Genotyping Assay.  Results: In study 1, genotype frequencies for ESR1 rs2234693 C/T were significantly different between the injured and noninjured groups in a C-allele dominant (CC + CT vs TT: odds ratio, 0.62; 95%confidence interval, 0.43–0.91) and additive (CC vs CT vs TT: odds ratio, 0.70; 95% confidence interval, 0.53–0.91) model in all athletes. In study 2, hamstring muscle stiffness was lower in subjects with the CC + CT genotype than in thosewith the TT genotype; a significant linear trend (CC G CT G TT)was found (r = 0.135, P = 0.029). In contrast, no associations were observed between ESR1 rs9340799 G/A and muscle injury or stiffness. Conclusions: Our results suggest that the ESR1 rs2234693 C allele, in contrast to the T allele, provides protection against muscle injury by lowering muscle stiffness.  － 21 －－  －0123456789

ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness

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ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness

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Tokyo Seiei College Repositories / 東京聖栄大学リポジトリ

ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness

Abstract

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Full text

Available Versions

Tokyo Seiei College Repositories / 東京聖栄大学 リポジトリ

Tokyo Seiei College Repositories / 東京聖栄大学リポジトリ