The T-box family of developmentally important transcription factors has been shown to play a role in the genesis of cancer and shows much promise for a targeted therapeutic approach. For example, the T-box factor TBX3 is overexpressed in a number of cancers including colorectal cancer but its precise role in the treatment of this disease still need to be clarified. We provide novel evidence to show that knocking down TBX3 sensitizes colorectal cancer cells to cisplatin treatment
