Background: This experimental study examined the effect of the antioxidant drug “U-74389Gâ€, on a rat model and particularly in a hypoxia – reoxygenation (HR) protocol. The effects of that molecule were studied hematologically using mean blood corpuscular volume (MCV) levels.Methods: 40 rats of mean weight 231.875 g were used in the study. MCV levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D) with administration of the drug U-74389G in groups C and D.Results: U-74389G administration significantly increased the predicted MCV levels by 2.88%+0.69 (p= 0.0002). Reoxygenation time non-significantly increased the MCV levels by 0.57%+0.83% (p=0.4103). However, U-74389G administration and reoxygenation time together significantly increased the MCV levels by 1.60%+0.43% (p= 0.0005).Conclusions: U-74389G administration whether it interacted or not with reoxygenation time has significant increasing short – term effect on recovery pathophysiology of MCV values
