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Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes
Authors
Matheus Dellaméa Baldissera
Dayana Lacerda Custódio
+12 more
Janice Luehring Giongo
Letícia Scherer Koester
Cristiane Bastos de Mattos
Sílvia González Monteiro
Camila Belmonte Oliveira
Michele Rorato Sagrillo
Paulo de Tarso Barbosa Sampaio
Aleksandro Schafer da Silva
Marcielly Souza de Matos
Helder Ferreira Teixeira
Rodrigo de Almeida Vaucher
Valdir F. Veiga-Junior
Publication date
1 January 2017
Publisher
'Elsevier BV'
Doi
Cite
Abstract
Aniba canelilla (H.B.K.) Mez, popularly known as “casca-preciosa” (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The present study aimed to report the chemical characterization of the oil extracted from Aniba canelilla using gas-chromatography/mass spectrometry and to assess its in vitro trypanocidal activity against Trypanosoma evansi, a prevalent haemoflagellate parasite that affects a broad range of mammal species in Africa, Asia and South America. The oil presented 1-nitro-2-phenylethane (83.68%) and methyleugenol (14.83%) as the two major components. The essential oil as well as both major compounds were shown to exert trypanocidal effect. Methyleugenol was slightly more active than 1-nitro-2-phenylethane. In vitro studies showed that the oil extracted from the stems of A. canelilla may be regarded as a potential natural treatment for trypanosomosis, once proven their in vivo action, may be an interesting alternative in the treatment of infected animals with T. evansi. © 2016 Elsevier Lt
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info:doi/10.1016%2Fj.micpath.2...
Last time updated on 07/11/2020
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