Purpose: This study aimed to report the characteristics and treatment outcome of 8 patients with solitary osseous plasmacytoma of the head and neck with special focus on mandibular plasmacytoma.Materials and Methods: The study was conducted on 8 patients with solitary osseous plasmacytoma of the head and neck who were treated at two academic tertiary referral hospitals between 1999 and 2010. All the patients were treated with curative intent. Four patients (50%) were primarily treated with radiotherapy alone at initial diagnosis, one patient (12.5%) underwent surgery alone, and 3 patients (37.5%) were treated with gross tumor resection followed by radiotherapy. The median total radiation dose was 46 (range 30-50) GY.Results: There were 4 women and 4 men aging from 37 to 73 years, with a median and mean age of 52 years at diagnosis. Pain (in 7 cases) and swelling (in 5 cases) were the most common presentations. Mandible (in 4 cases) was the most frequent primary site. The median tumor size was 4.8 (range 3.5-6) cm. After a median follow-up of 44 months (range 27-79 months), 5 patients are alive and without disease, one is alive with multiple myeloma, and two died of multiple myeloma.Conclusion: Solitary osseous plasmacytomas of the head and neck have a propensity to involve the mandibular bones and response well to effective local treatments of radiotherapy and/or surgery. These Patients tend to progress to multiple myeloma even years after the initial treatment
