Breast cancer is one of the most commonly diagnosed malignancies in women around the world. Chromosomal rearrangements are known to play important role in the pathogenesis of many diseases including cancer. In case of breast cancer, chromosomal changes are detectable at all stages of tumour development providing excellent opportunity for prognosis and therapy. Present work aimed to study the frequency of chromosomal aberrations and satellite associations in human peripheral blood lymphocyte culture of freshly diagnosed breast cancer patients after in vitro exposure to combination of anticancer drug treatment. The present study reveals that, combination of anticancer drugs significantly increases chromosomal aberrations without altering the frequency of satellite associations
