We reviewed the literature on sunlight-induced DNA damage that leads to cancer in humans. Topics covered in this review are an introduction to sunlight radiation and examples of photo-induced DNA damage. The studies on sunlight radiation are covered in a brief discussion of ultraviolet (UV) and UV wavelengths such as UV-A, UV-B and UV-C that are known to induce cancer. The current literature covering a variety of cellular interactions with the UV component of sunlight from the point of view of photoactivated processes are discussed. We also discuss the chemical products of DNA sunlight induced damage. Based on the literature reviewed, a conclusion can be drawn that the UV component of sunlight is the most important epidemiological factor associated with an increased risk of human cancer. Sunlight-induced DNA damage also affects tissue homeostasis
