Organic-inorganic hybrids (OIH) are considered to be a powerful platform for applications in many research and industrial fields. This review highlights the application of OIH for chemical analysis, biosensors, and environmental monitoring. A methodology toward metrological traceability measurement and standardization of OIH and demonstration of the role of mathematical modeling in biosensor design are also presented. The importance of the development of novel types of OIH for biosensing applications is highlighted. Finally, current trends in nanometrology and nanobiosensors are presented
