Background: Cinnamon is a spice which has been in use for 1000 of years for its taste, condiment, and for its medicinal values. It has a history of medicinal use in China, Egypt, and Europe. In traditional medicine, cinnamon is used in respiratory, digestive, and skin ailments. It has anti-inflammatory, antibacterial, antidiabetic, antiarthritic, anticlotting, and immune regulatory properties. Cinnamon oil is used topically in the treatment of certain skin diseases such as acne, eczema, and pimples. In recent times, there has been a gradual rise in interest in the use and research on medicinal plants the world over due to their safety margin and minimal side and adverse effects. Aim: This paper aims to review the available scientific literature and to provide a comprehensive summary on the potential medicinal benefits of cinnamon in orofacial disease conditions. A review of the scientific literature available on cinnamon conclusively proves its efficacy in the management of several ailments including metabolic disorders like diabetes and lifestyle-associated conditions like hyperlipidemia. Conclusion: A review of its mechanism of action indicates its potential therapeutic benefit in the management of various orofacial conditions including trigeminal neuralgia and lichen planus. Clinical Significance: Cinnamon unfortunately like any medications does have its share of adverse effects and reactions, and therefore, its clinical use must be paved with caution and planned clinical trials, keeping in mind its potential adverse effects and interactions will result in a more standard formulation and protocol for the use of cinnamon as a therapeutic agent
