Calvão-Santos, G

Gentil, R

Leite, R

Mendes, J

Mendonça, L

Sousa, K

Sousa, N

English

Institutional repository of Hospital de Braga

   EFFECT OF TRIAMCINOLONE INTRAVITREAL INJECTION IN PREVIOUSLY VITRECTOMIZED EYES     Nuno Gomes, Keissy Sousa, Luis Mendonça, Rita Gentil, Gil Calvão-Santos, Ricardo Leite, José Mendes  Hospital de Braga, Portugal   2 Intravitreal  triamcinolone acetonide (IVTA) has been shown to improve visual acuity (VA) and reduce  central macular thickness (CMT) in different pathologies  IVTA is associated with a low incidence of surgical complications but with some well-known  side effects (increase in intraocular pressure, cataract development)  The recurrence of edema is related to the disappearance of triamcinolone from the vitreous: a mean elimination half-life of 18.6 days has been described and it was estimated that 4 mg of triamcinolone would last in the vitreous for approximately 3 months.  In theory, the half-life of this drug should be smaller in previously vitrectomized eyes  due to the lack of the vitreous reservoir and a faster wash-out from the vitreous cavity.   3 PURPOSE To analyse the effect of IVTA on CMT in previously vitrectomized eyes.       METHODS Retrospective study, Hospital de Braga, Ophthalmology Department Eyes with macular edema that had previously underwent 23G pars plana vitrectomy.  The following parameters were analyzed before and after IVTA: •  Best Corrected Visual Acuity (BCVA),  •  Intra-ocular Pressure (IOP), •  Mean CMT using Optical Coherence Tomography (Cirrus HD-OCT Zeiss®). We compared the change in mean CMT and its duration over time.  Statistical analysis were performed using paired-sample t-test.  4 RESULTS 11 pseudophakic eyes of 9 patients were included as shown below.  Age (years) Mean (±SD) 68.2 (±8.65) Range 57-81 Sex (n) Male 4 Female 5 Eye (n) Right Eye 6 Left Eye 5 Mean time between PPV and IVTA (months) Mean (±SD) 11.12 (±4.5) Range 2.3 – 14.8 Cause Diabetic Macular Edema 9 Trauma 1 Rhegmatogenous Retinal Detachment 1 5 0 100 200 300 400 500 600 700 1 2 3 4 5 6 7 8 9 10 11 Patient CMT before and after IVTA per patient Before IVTA After 1st IVTA After 2nd IVTA 6 CMT reduction lasted a mean (±SD) of 11.62±3.46 weeks.  CONCLUSIONS Triamcinolone should be considered in the treatment of patients with persistent macular edema in vitrectomized eyes. CMT lowering effect of triamcinolone in vitrectomized eyes approached the time-range of 12 to 14 weeks usually seen in non-vitrectomized eyes.  

Effect of triamcinolone intravitreal injection in previously vitrectomized eyes

http://repositorio.hospitaldebraga.pt/bitstream/10400.23/791/1/Poster%20Euretina%2011%20a%2014%20setembro%202014.pdf

Effect of triamcinolone intravitreal injection in previously vitrectomized eyes

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