Alves, M

Fernandes, V

Marques, O

Monteiro, AM

Souto, S

English

Institutional repository of Hospital de Braga

CLINICAL AND HISTOLOGICAL DIFFERENCES OF PAPILLARY THYROID CARCINOMAIN PATIENTS WITH CHRONIC LYMPHOCYTIC THYROIDITISINTRODUCTIONThe relationship between chronic lymphocytic thyroiditis (CLT) and papillarythyroid carcinoma (PTC) is controversial since its first description, continuing to bean area of ongoing research.The objectives of this study was the determination of prevalence of CLT inpatients with PTC and evaluation of the clinicopathological differences of PTC inpatients with and without CLT.MATERIAL AND METHODSA retrospective study of consecutive patients admitted to our hospital for thetotal thyroidectomy for PTC, between Jan/2009 and Jun/2014. Patients with othertypes of tumor histopathology and without enough data in the clinical processwere excluded. CLT was diagnosed based on histology of the surgical piece.Statistical analysis: IBM SPSS (v.20) - χ2, Fisher exact test, Student's t and Mann-Whitney. Statistical significance: p<0.05.RESULTSDISCUSSIONIn this study, there were no statistically significant differences between groups (with and without CLT) in the different clinical and pathological characteristics of PTC that influence the prognosis of the tumor. However, there were a statistical trend for smaller tumor size in patients with CLT as well as lower lateral cervical lymph node involvement, as suggested by some studies in the literature.REFERENCESGirardi F.M., et al, Papillary thyroid carcinoma: does the association with Hashimoto’s thyroiditis affect the clinical---pathological characteristics of the disease?, Braz J Otorhinolaryngol. 2014; Zhang, Y. D. et al, The study of coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol, pp. 1021-1026, 2014; Jankovic B., Le K.T., Hershman J.M., Hashimoto’s Thyroiditis and PapillaryThyroid Carcinoma: Is there a Correlation?, J Clin Endocrinol Metab, February 2013, 98(2):474-482; Marotta V. et al, BRAF mutation positive papillary thyroid carcinoma is less advanced when Hashimoto’s thyroiditis lymphocytic infiltration is presente, Clinical Endocrinology, 733–738, 2013; ; Jara, S. M. et al The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in NorthAmerican patients with papillary thyroid carcinoma. Surgery, 154(6), pp. 1272-1282., 2013 ; Lee J.H. et al, The association between papillary thyroid carcinoma and histologically proven Hashimoto’s thyroiditis: a meta-analysis, European Journal of Endocrinology, 168: 343-349, 2013; Zhang et al, The clinical features of papillary thyroid cancer in Hashimoto’s thyroiditis patients from an area with a high prevalence ofHashimoto’s disease, BMC Cancer 12:610, 2012; Jeong J.S. et al, Coexistence Of Chronic Lymphocytic Thyroiditis With Papillary Thyroid Carcinoma: Clinical Manifestations And Prognostic Outcome, J Korean Med Sci, 27, 883-889, 2012; Yoon, Y. et al, The The clinicopathologic diVerences in papillary thyroid carcinoma with or without co-existing chronic lymphocytic thyroiditis, Eur Arch Otorhinolaryngol, 269:1013–1017, 2012; Paulson L.M., Role Of Chronic Lymphocytic Thyroiditis In Central Node Metastasis Of Papillary Thyroid Carcinoma, Otolaryngology-Head And Neck Surgery, 147(3), 2012; Marotta V. et al, RET/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint, European Journal of Endocrinology, 165 499–507, 2011; Kim E.Y. et al, Coexistence of chronic lymphocytic thyroiditis is associatedwith lower recurrence rates in patients with papillary thyroid carcinoma, Clinical Endocrinology,71, 581-586, 2009Table 1 – Demographic characteristics of study population (n=119)Variables With CLT Without CLT All p valueAge (years) (mean; SD) 45.5 ± 13.3 47.7 ± 14.2 46.9 ± 13.9 0.41Female sex (n; %) 37.0; 92.5 66.0; 83.5 103.0; 86.6 0.18CLT: chronic lymphocytic thyroiditis; SD: standard deviationTable 2 – Clinical and pathological characteristics of  papillary thyroid carcinoma (n=119)Variables With CLT Without CLT All p valueTumour size (mm) (median; IQR) 11.0; 7.0 14.0; 11.0 12.0; 9.0 0.055Multifocality (%) 31.6 35.0 32.8 0.713Extrathyroidal extension (%) 50.0 62.0 58.0 0.209Linfatic invasion (%) 35.0 44.3 41.2 0.330Vascular invasion (%) 15.0 17.7 16.8 0.708Central lymph nodes metastasis (%) 32.5 40.5 37.8 0.395Lateral lymph nodes metastasis (%) 5.0 16.5 12.6 0,075Distance metastasis (%) 0.0 1.3 1.7 1.0CLT: chronic lymphocytic thyroiditis; IQR: interquartile range66,4% (n=79)33,6% (n=40)Graph 1: Prevalence of chronic lymphocytic thyroiditis (CLT) Without CLT With CLTAna Margarida Monteiro, Vera Fernandes, Selma Souto, Olinda Marques, Marta AlvesDepartment of Endocrinology, Hospital de BragaPoster Number P2-01-07

Clinical and histological differences of papillary thyroid carcinoma in patients with chronic lymphocytic thyroiditis

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Clinical and histological differences of papillary thyroid carcinoma in patients with chronic lymphocytic thyroiditis

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