A Eliakim

CK Natarajan

CM Vignochi

D Nemet

E Erdem

EE Ziegler

GB Forbes

I Litmanovitz

JC Callenbach

JL Ballard

JR James

L Moyer-Mileur

LJ Moyer-Mileur

LJ Moyer–Mileur

MC Blackstrom

O Tosun

R Agarwal

RB Mazess

SM Schulzke

AbstractObjectiveTo compare the efficacy of daily assisted physical exercise (starting from one week of postnatal age) on bone strength at 40 weeks of post menstrual age to no intervention in infants born between 27 and 34 weeks of gestation.DesignOpen-label randomized controlled trial.SettingTertiary-care teaching hospital in northern India from 16 May, 2013 to 21 November, 2013.Participants50 preterm neonates randomized to Exercise group (n=26) or Control group (n=24).InterventionNeonates in Exercise group underwent one session of physical exercise daily from one week of age, which included range-of-motion exercises with gentle compression, flexion and extension of all the extremities with movements at each joint done five times, for a total of 10-15 min. Infants in Control group underwent routine care and were not subjected to any massage or exercise.Outcome measuresPrimary: Bone speed of sound of left tibia measured by quantitative ultrasound at 40 weeks post menstrual age.Secondary: Anthropometry (weight length and head circumference) and biochemical parameters (calcium, phosphorus, alkaline phosphatase) at 40 weeks post menstrual age.ResultsThe tibial bone speed of sound was comparable between the two groups [2858 (142) m/svs. 2791 (122) m/s; mean difference 67.6 m/s; 95% CI -11 to 146 m/s;P=0.38]. There was no difference in anthropometry or biochemical parameters.ConclusionDaily assisted physical exercise does not affect the bone strength, anthropometry or biochemical parameters in preterm (27 to 34 weeks) infants.</jats:sec

Subhash Chandra Shaw

Mari Jeeva Sankar

Anu Thukral

Chandra Kumar Natarajan

Ashok K. Deorari

Vinod K. Paul

Ramesh Agarwal

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Indian Pediatrics

Assisted Physical Exercise for Improving Bone Strength in Preterm Infants Less than 35 Weeks Gestation: A Randomized Controlled Trial

Assisted Physical Exercise for Improving Bone Strength in Preterm Infants Less than 35 Weeks Gestation: A Randomized Controlled Trial

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