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鲤TYK2基因的克隆鉴定及组织表达分析
Authors
付友
刘德立
+4 more
吴平
文春根
袁永泽
高谦
Publication date
1 January 2015
Publisher
Abstract
两面神激酶(JAK,Janus kinase)是一类酪氨酸蛋白激酶(PTK,protein tyrosine kinase),迄今已发现有4个成员,即JAK1、JAK2、JAK3和TYK2(Tyrosine kinase 2),JAK分子具有7个独特的结构域,从C端到N端依次为JAK同源区1(JAK homology 1,JH1)-JH71。细胞因子与相应受体结合后,JAK与受体偶联并发生酪氨酸磷酸化而激活,活化的JAK能催化受体上特定部位的酪氨酸残基磷酸化,形成信号转导和转录激活因子(Signal Transducer and Activator of Transcription,STAT)等含Src同源区2(SH2,Sr
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Institute of Hydrobiology, Chinese Academy Of Sciences
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Last time updated on 23/01/2021